Work

Co-occurrence of peritoneal mesothelioma and genitourinary cancers: a case series with comparative outcomes

Year: 2025

Type: article

Abstract: Objectives Peritoneal mesothelioma (PM) shares features with genitourinary (GU) malignancies, including histologic appearance, embryologic origin and genetic predispositions. However, data on their co-occurrence are limited. The study presents a case series of PM patients with associated GU malignancies and explores outcomes following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC). Methods A prospectively maintained CRS-HIPEC database from a tertiary referral center (2011–2024) was reviewed. Demographics, tumor characteristics and outcomes were compared between PM patients with and without GU malignancies (including gynecologic and urologic cancers). Results Among 237 CRS-HIPEC patients, 8/17 patients with PM were found to have another GU malignancy (median age 52.8, 62.5 % male). This included renal cell carcinoma, prostate cancer, ovarian tumors and cervical carcinoma. Most GU malignancies were diagnosed before PM (5/8), two were diagnosed post-CRS-HIPEC, and one synchronously. Three patients reported asbestos exposure; two had BAP1 mutations. Compared to those without GU malignancies, affected patients tended to have higher PCI (19.8 vs. 14.3) and poorer 3-year survival (62.5 vs. 100 %). Conclusions GU malignancy is common among PM patients undergoing CRS-HIPEC and could represent a higher-risk subgroup. These findings raise the hypothesis of a potential association between PM and GU malignancy. Shared origins, oncogenesis of similar cell types, environmental exposures or genetic predispositions may contribute and warrant further investigation.

Source: Pleura and Peritoneum

DOI: 10.1515/pp-2025-0020

Authors: Emma M. Bradley, James L. Rogers, Marissa C. Kuo, Deepa Magge

Institutions: Vanderbilt University, VA Tennessee Valley Healthcare System, Vanderbilt University Medical Center

Language: English

Topic: Intraperitoneal and Appendiceal Malignancies

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,187