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Colorectal cancer in a man with silver-Russell syndrome: a case report

Year: 2025

Type: article

Abstract: Silver-Russell syndrome (SRS), also known as Russell-Silver syndrome (RSS), is a congenital growth disorder characterized by intrauterine and postnatal growth retardation, craniofacial disproportion, asymmetry, and other distinctive features. It was first described by Alex Russell and Henry Silver in the 50s of the 20th century. Its broad range of manifestations makes its true incidence difficult to determine. While gastrointestinal anomalies such as gastroesophageal reflux disease and esophagitis have been reported in SRS patients, an association with colorectal cancer (CRC) has not been described. Here, we present the case of a 31-year-old man with SRS who was referred to us for constipation. A rectal biopsy revealed moderately differentiated adenocarcinoma, and a staging CT scan demonstrated multiple lung and hepatic nodules.

Source: Oxford Medical Case Reports

DOI: 10.1093/omcr/omaf204

Authors: Farah Ibraik, Ibraheem Hammouri, Hasan Arafat, Ahmad G Hammouri, Hanna Qahoush

Institutions: An-Najah National University, Palestine Polytechnic University, Augusta Victoria Hospital, Ahli Hospital

Language: English

Topic: Genetic factors in colorectal cancer

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,103