Work

Respiratory infections and asthma exacerbations in children: Regional insights into the overlooked role of atypical pathogens in Mexico

Year: 2025

Type: article

Abstract: Background: Respiratory infections are the leading cause of asthma exacerbations in children, yet data from Latin America remain limited, especially in the postpandemic context. Understanding the respiratory pathogen landscape in pediatric patients with wheezing episodes may inform regional management strategies. Objective: We sought to characterize the prevalence of respiratory pathogens, including atypical viruses and bacteria, in children with asthma or recurrent wheezing in 2 distinct regions of Mexico. Methods: We conducted a retrospective study of 432 children (aged 2-17 years) with a history of asthma or wheezing and current lower respiratory tract symptoms. Nasopharyngeal swabs were collected between January 2021 and September 2022 at tertiary centers in Mexico City and Oaxaca. Multiplex PCR detected 16 viruses and 3 atypical bacteria. Severe acute respiratory syndrome coronavirus 2 was tested separately by RT-PCR. Statistical comparisons were performed by region and age group. Results: = .008). Conclusions: were frequently detected in children with wheezing in postpandemic Mexico. Findings highlight regional disparities in pathogen circulation and the need for enhanced surveillance and vaccination strategies across Latin America.

Source: Journal of Allergy and Clinical Immunology Global

DOI: 10.1016/j.jacig.2025.100597