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Tirofiban-Induced Diffuse Alveolar Hemorrhage in a Patient With Acute Myocardial Infarction Following Primary Percutaneous Coronary Intervention: A Case Report

Year: 2025

Type: article

Abstract: This case report presents a rare instance of tirofiban-induced diffuse alveolar hemorrhage (DAH) in a 66-year-old male undergoing primary percutaneous coronary intervention for acute myocardial infarction. Approximately 22 hours after tirofiban initiation, the patient developed acute dyspnea and hemoptysis. Imaging studies revealed bilateral alveolar infiltrates consistent with DAH, accompanied by a significant drop in hemoglobin. Cessation of tirofiban and dual antiplatelet therapy led to rapid clinical improvement within 24 hours, with complete radiological resolution observed by day 15. Other potential etiologies were ruled out through serological testing. This case highlights DAH as a serious, albeit rare, complication of glycoprotein IIb/IIIa inhibitor therapy and emphasizes the importance of early recognition and immediate drug discontinuation to ensure favorable outcomes.

Source: Cureus

DOI: 10.7759/cureus.95855

Authors: Xiaoyan Li, Guoqing Qi, Liye Wei

Institutions: Hebei Medical University, First Hospital of Shijiazhuang, First Affiliated Hospital of Hebei Medical University

Language: English

Topic: Antiplatelet Therapy and Cardiovascular Diseases

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4415758266