Work

An Outbreak of Vitamin D Toxicity in a Family: Report of 3 Cases From Unregulated Fortification

Year: 2025

Type: article

Abstract: Vitamin D toxicity is a rare but potentially life-threatening cause of PTH-independent hypercalcemia. While most cases result from inappropriate supplement use, food-related exposures are increasingly recognized. We report a cluster of 3 adults from the same household who presented within 3 days with severe hypercalcemia and acute kidney injury. All had markedly elevated 25-hydroxyvitamin D, suppressed intact PTH, and a shared history of consuming locally sourced, unpackaged cooking oil. Liquid chromatography–tandem mass spectrometry analysis of the retained oil confirmed toxic vitamin D3 contamination at 1286 μg/mL (SI: ∼3.34 × 106 nmol/L). Treatment included IV fluids, calcitonin, and denosumab; 1 required dialysis. All recovered fully. This case series highlights the need to consider dietary sources in familial hypercalcemia and underscores the importance of regulating food fortification and edible product safety.

Source: JCEM Case Reports

DOI: 10.1210/jcemcr/luaf230

Authors: Vivek Jha, Rahul Rouniyar, Sudhaker Dhanwada Rao, Ajit Dua, Sanjay Kumar Bhadada

Institutions: Post Graduate Institute of Medical Education and Research, Henry Ford Health, Henry Ford Hospital

Language: English

Topic: Vitamin D Research Studies

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDGs: Good health and well-being, Zero hunger

Open Access status: gold

Estimated APC paid: $930