Exploring diversity in Non-Alcoholic Fatty Liver Disease (NAFLD) among lean, overweight, and obese patients: A Multicenter study from India
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: One common chronic liver illness is non-alcoholic fatty liver disease (NAFLD) affecting individuals across various body weights. Traditionally associated with obesity, NAFLD is now increasingly observed in overweight and lean individuals as well. This research investigates the clinical, metabolic, dietary pattern, and socio-demographic differences of NAFLD in lean, overweight, and obese individuals across various centers in two Indian states. Methodology: Conducted as a cross-sectional observational study with 154 NAFLD patients aged 18-65 years across four centers [Odisha (OD) -3; Uttar Pradesh (UP) -1], the research utilized a self-administered questionnaire to gather socio-economic, biochemical, and clinical data. Data analysis involved Chi-square tests at a 0.05 significance level. Trail Registration: CTRI/2024/04/065699. Result: The majority of NAFLD cases were found in obese patients (37.01% in Odisha and 35.06% in UP). Overweight NAFLD was more common in UP (10.39%), while lean NAFLD was more prevalent in Odisha (7.14%). Obesity was significantly associated with diabetes in both states (p=0.020). Constipation was notable in overweight and obese groups (p=0.001 and p=0.027), and bloating was more frequent in overweight individuals (p=0.064). Loss of appetite was significant among lean NAFLD patients. Biochemical parameters and food consumption across ten food groups showed no significant variation. Conclusion: Overall, NAFLD was more common among obese patients, highlighting the need for tailored dietary interventions based on body type.
Source: PubMed
Authors: Sahoo, Prangya Paramita, Yadav, Dawesh Prakash, Singh, Mukta, Prahraj, Dibyalochan, Singh, Ayaskanta, Uthansingh, Kanishka, Sahu, Manoj Kumar, Pati, Girish Kumar
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4415764361
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