Synthesis of chiral α-alkynyl-α-hydroxyamides by enantioselective alkynylation of α-keto amides
Year: 2025
Type: article
Abstract: Zn-mediated addition of terminal alkynes to α-keto amides. The desired products are obtained in good yields and enantioselectivities with broad substrate and reagent scopes.
Source: Organic & Biomolecular Chemistry
DOI: 10.1039/d5ob01546d
Authors: Elena Prieto, Celia Andrés, Javier Nieto
Institution: Universidad de Valladolid
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Funder: Junta de Castilla y León
Awards: G1990977243, G4365598639, G4762817603
OpenAlex ID: W4415764950