Year: 2025
Type: article
Abstract: Background Understanding resilience mechanisms is important for advancing early intervention strategies, yet research on the neurobiology of resilience in adolescents is limited. The present study examined the brain structural and resting‐state functional connectivity (rsFC) correlates of resilience to internalizing and externalizing symptoms in a large sample of adolescents. Methods We analyzed longitudinal data from 8499 adolescents (baseline mean age 9.92 ± 0.62 years) from the Adolescent Brain Cognitive Development Study. Participants were categorized as resilient, maladaptive, vulnerable, or control group based on reports of traumatic events and internalizing/externalizing symptoms 3 years later. We used multinomial regressions to examine associations of brain structure (gray matter, N = 7526; white matter, N = 6959) and rsFC ( N = 6485) with resilience. Sex differences were also investigated. Results For internalizing symptoms, increased odds of being resilient (relative to controls) were associated with postcentral gyrus thickness. For externalizing symptoms, increased odds of being resilient was associated with putamen volume (relative to being vulnerable), and rsFC between the dorsal and ventral attention networks, and between cortical networks and hippocampus (relative to controls). Sex‐interaction results implicated gray matter structure, however, robustness of these findings are limited. Conclusion Resilience in the context of internalizing symptoms in adolescence may be associated with structural alterations in cortical regions involved sensory processing. Neural correlates of resilience in the context of externalizing symptoms remain unclear as findings may reflect resilience, trauma exposure, or psychopathology. This underscores the need for further research into the neurobiological basis of resilience during adolescence.
Source: JCPP Advances
DOI: 10.1002/jcv2.70066
Language: English
Topic: Resilience and Mental Health
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: gold
Estimated APC paid: $2,705
Awards: G9000046731, G9000061868, G9000108491, G9000113866, 9/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT U MICHIGAN, 20/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT VCU, 3/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT U MINNESOTA, 4/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT FIU, 7/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT YALE, 17/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT UCLA, 16/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT UNIVERSITY OF ROCHESTER, 8/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT CHLA, ABCD-USA Consortium: Coordinating Center, 6/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT OHSU, 12/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT U PITTSBURGH, 19/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT UVM, 1/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT U UTAH, 11/21 ABCD-USA Consortium: Research Project Site at UWM, ABCD-USA Consortium: Data Analysis, Informatics and Resource Center, 21/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT WUSTL, 13/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT MUSC, 5/21 ABCD-USA Consortium: Research Project Site at UC San Diego, 2/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT UMB
OpenAlex ID: W4415774005