Work

Electrochemical assessment of α-amylase inhibition by type 2 diabetes drugs: a cyclic voltammetry study

Year: 2025

Type: article

Abstract: A new sensitive cyclic voltammetry method was developed for measuring the α-amylase inhibitory activity of six antidiabetic drugs commonly prescribed for type 2 diabetes: acarbose, amaryl, repaglinide, diamecron, dapagliflozin, and metformin. The electrochemical response of an enzyme-starch mixture was measured in the absence and presence of these drugs. Results indicated varying inhibitory potencies with IC50 values ranging from 6.770 to 41.423 µM, with acarbose as the most potent. UV-Vis absorption spectroscopy at 580 nm validated the cyclic voltammetry results, with very good concordance. This study highlights the utility of electrochemical assays for the rapid, quantitative screening of α-amylase inhibitors and supports their integration with spectroscopic methods for the evaluation of antidiabetic drugs.

Source: Journal of Electrochemical Science and Engineering

DOI: 10.5599/jese.2867

Authors: Touhami Lanez, Elhafnaoui Lanez, Aicha Adaika

Institution: University of Eloued

Language: English

Topic: Electrochemical sensors and biosensors

Subfield: Electrical and Electronic Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Ministère de l'Education Nationale, de l'Enseignement Superieur et de la Recherche, Direction Générale de la Recherche Scientifique et du Développement Technologique