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Schisantherin A induces ferroptosis in non‑small cell lung cancer through activation of the YAP/ACSL4/TfR signaling pathway

Year: 2025

Type: article

Abstract: , Sch A significantly inhibited subcutaneous tumor growth in nude mice. In conclusion, Sch A may activate the YAP/ACSL4/TfR signaling axis to induce ferroptosis in NSCLC cells, positioning it as a potential small‑molecule therapeutic agent for NSCLC.

Source: Molecular Medicine Reports

DOI: 10.3892/mmr.2025.13734

Authors: Wenxiang Zhu, Yeyang Chen, Xiangjian Wu, Xiaoyan Fu, Yongshi He, Yuxia Mo, Qinghua Zhu, Mingwen Tang, Zhiguang Zhai

Institutions: Guangzhou University of Chinese Medicine, Shenzhen Traditional Chinese Medicine Hospital, Hong Kong Baptist University, China Academy of Chinese Medical Sciences, Institute of Basic Theory for Chinese Medicine

Language: English

Topic: Ferroptosis and cancer prognosis

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4415782459

FWCI: 1.772

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Cited by: 3

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