Figure 3 from Divergent Clonal Evolution and Early Dissemination Promote Genetic Heterogeneity of Metastases in Castration-Resistant Prostate Cancer
Year: 2025
Type: other
Abstract: Heterogeneity of recurrent prostate cancer CN alterations across metastatic sites. A, Top, heterogeneity in tumor ploidy across metastatic sites. Bottom, proportion of patients with truncal, heterogeneous, or no observed WGD events. B, Cohort-wide frequency of CN gains (red) and losses (blue). C, Proportion of patients with losses (left) and gains (right) on recurrently deleted and amplified regions in mCRPC. Shading indicates truncal (dark) and heterogeneous observations (per-patient). D, Heterogeneity of AR CN and mutation status across metastatic sites. Blue, presence of AR mutations. Absolute copy estimates are capped at 35. WT, wild-type. E, Increase in the detection rate of CN losses as a function of the number of sites sampled. Select loci recurrently altered in prostate cancer are highlighted. F, Increase in the detection rate of CN losses as a function of the number of sites sampled. Select loci recurrently altered in prostate cancer are highlighted.
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4415786203
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