Figure 1 from Divergent Clonal Evolution and Early Dissemination Promote Genetic Heterogeneity of Metastases in Castration-Resistant Prostate Cancer
Year: 2025
Type: other
Abstract: Overview of the cohort and ubiquitous alterations across metastatic tumors in mCRPC. A, Overview of the cohort by number of patients and samples obtained from each tissue. B, Patients and their corresponding sequenced tissue sites. Some of the patients might have multiple tumors from the same site. The “other” category includes tissues for which fewer than six tumors are obtained. C, Alteration landscape of the cohort. Likely driver genes, which are commonly altered in prostate cancer and altered at least once in this cohort, are included. LOH is only shown when it is accompanied by a mutation. D, Proportion of patients with alterations in genes recurrently altered in prostate cancer (alterations shown in C). Among CNV alterations, only homozygous deletions and amplifications have been considered. E and F, Proportion of mutations classified as present and clonal in all sites as a function of the number of sites evaluated. E, All patients. F, Patients with at least four sites sequenced. Significance based on the Wilcoxon rank-sum test. G, CCF of mutations in prostate cancer recurrently mutated genes compared with all other detected mutations. Amp, amplification; Avg, average; del, deletion; met, metastasis, Non-Syn, nonsynonymous.
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4415786208
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