Work

Injectable ultrasonic metagels for intracranial monitoring

Year: 2025

Type: article

Abstract: Annually, over 10 million patients undergo high-risk invasive intracranial monitoring, facing risks of infection and secondary surgeries. Injectable ultrasonic metagels, wireless, biodegradable sensors with air-column matrices for multiparameter (pressure, temperature, pH, flow) ultrasound readout, are delivered via 5.8 mm burr-hole/22 G needle (avoiding ≥10 mm craniotomy), enabling ambulatory monitoring. Biodegradation eliminates removal surgery, addressing biocompatibility, fidelity, and deployability. However, unresolved degradation kinetics, motion artifact, and deep-tissue signal require resolution for further clinical translation.

Source: npj Biosensing

DOI: 10.1038/s44328-025-00058-7

Authors: Yuchun Wang, Minyan Ge, Ru Wang, Yinghao Zhu, Shumao Xu

Institutions: Fudan University, Max Planck Institute for Solid State Research

Language: English

Topic: Hydrogels: synthesis, properties, applications

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,590