Analysis of the clinical characteristics and prognostic factors of multicenter childhood Burkitt leukemia
Year: 2025
Type: article
Abstract: Burkitt lymphoma (BL) is a B-cell malignancy with a rapid doubling time, originating in follicular germinal centers. We aimed to explore the characteristics and prognosis of childhood Burkitt leukemia. A total of 124 children with Burkitt leukemia enrolled during the 6-year period of China Net Childhood Lymphoma- mature B-cell lymphoma 2017 regimen (CNCL-B-NHL-2017) were assessed. The median age at onset was 7 years (1-15 years), with a male-to-female ratio of 4.17:1. Of the total, 50.8% children were aged 5-10 years. Children with Burkitt leukemia were more likely to have tumor lysis syndrome, renal insufficiency, lactate dehydrogenase (LDH) > 4 times, multiple organ involvement, and central nervous system infiltration at diagnosis, whereas those with large tumor mass were rare. Eleven children had pure Burkitt leukemia (8.9%), with no significant differences in relapse, progression, white blood cell counts at initial diagnosis, LDH levels, CNS infiltration, and rates of tumor lysis syndrome before treatment compared to those of children with tumor masses. (P > 0.05). The median follow-up time for the entire group was 32.85 months (0.4-70.7), with 3-year overall survival and event-free survival rates of 87.1% and 81.5%, respectively. Thirteen (10%) children progressed or relapsed during treatment, of which nine received chimeric antigen receptor T-cell therapy, with only three fatalities. The analysis identified residual disease at midterm evaluation (P = 0.024) and LDH elevation ≥ 2000 U/L (P = 0.014) as independent prognostic factors affecting survival. The CNCL-B-NHL-2017 protocol demonstrated significant efficacy in treating children with Burkitt leukemia.
Source: Annals of Hematology
Authors: Wenting Pei, Yanlong Duan, Ling Jin, Xiaomei Yang, Yunpeng Dai, Mincui Zheng, Leping Zhang, Ying Liu, Xiaojun Yuan, Kailan Chen, Lirong Sun, Jian Jiang, Xiaowen Zhai, Ansheng Liu, Rong Liu, Jian Wang, Wei Liu, Baoxi Zhang, Yufeng Liu, Xige Wang, Lian Jiang, Lihua Yang, Chunju Zhou, Zifen Gao, Yonghong Zhang, Fu Li
Institutions: Shandong University, Capital Medical University, Beijing Children’s Hospital, Shandong Provincial Hospital, Shandong First Medical University, Hunan Children's Hospital, Peking University, Peking University People's Hospital, First Affiliated Hospital of Zhengzhou University, Shanghai Jiao Tong University, XinHua Hospital, Wuhan Children's Hospital, Huazhong University of Science and Technology, Affiliated Hospital of Qingdao University, Children's Hospital of Fudan University, Xi’an Children’s Hospital, Capital Institute of Pediatrics, Children's Hospital of Capital Institute of Pediatrics, Anhui Provincial Children's Hospital, Zhengzhou University, Zhengzhou Children's Hospital, Hebei Medical University, Second Hospital of Hebei Medical University, Third Affiliated Hospital of Zhengzhou University, Fourth Hospital of Hebei Medical University, Zhujiang Hospital, Southern Medical University
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,590
OpenAlex ID: W4415786941