Figure 3 from Decoding the Genomic and Functional Landscape of Emerging Subtypes in Ovarian Cancer
Year: 2025
Type: other
Abstract: Subtype discovery. The SCN signature activity profiles have been clustered into six subtypes with ConsensusClusterPlus and annotated in different colors beneath the dendrogram. The accompanying barplot illustrates signature activity values, with each color representing a distinct signature. Annotations below the main barplot include mutational HR status and the presence of specific gene alterations, such as CDK12, BRCA1, and BRCA2 mutations, as well as CCNE1, MYC, and AKT2 amplifications. A heatmap also displays the counts of complex structural variations (SV) using a color-coded scale. The purple bar plot below indicates the number of breakpoints, the red track with light blue dots represents the tumor mutational burden (TMB), and the amount of long interspersed nuclear elements (LINE) in each sample is shown as a heatmap in the bottom annotation. Notably, AKT2 amplification and CDK12 mutation are mutually exclusive to HRD clusters, whereas CCNE1 and MYC amplifications are present in both HRP and HRD compartments. Moreover, HRD subtypes and the proliferative HRD subtype are characterized by high TMB and number of breaks, and the proliferative subtype is enriched in pyrgos and chromoplexy. Further visualization of the clusters is available at GenomeSpy_6.
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4415787106