Case Report: Pediatric palisaded neutrophilic and granulomatous dermatitis without systemic diseases treated with sulfasalazine
Year: 2025
Type: article
Study design: Case Report
Abstract: Palisaded neutrophilic and granulomatous dermatitis (PNGD) is a rare neutrophilic dermatosis strongly associated with systemic conditions. Pediatric cases with exclusive cutaneous involvement are exceptionally rare. Current treatment options for PNGD include oral dapsone, hydroxychloroquine, and intralesional or systemic corticosteroids. Here we report a 6-years-old girl with skin-limited PNGD, presenting symmetric annular plaques on limb extensor surfaces and atypical lesions on the face, palms, and buttocks. Significant lesion resolution was achieved after 2 months of oral sulfasalazine therapy (25 mg/kg/day in divided doses), with only mild abdominal discomfort. To our knowledge, this represents the first successful use of sulfasalazine for PNGD, providing a dapsone-sparing alternative for pediatric PNGD.
Source: Frontiers in Medicine
Authors: Qiuyang Guo, Yumeng Wang, Qiuyi Han, Jinxiang Yang, Jiayan Zhang, Guofang Li, Yijun Yang, Ruhong Cheng, Zhirong Yao
Institutions: Shanghai Jiao Tong University, XinHua Hospital
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
Award: G680324159
OpenAlex ID: W4415796972