Susceptibility and resistance of Gram-negative bacteria to a novel antimicrobial agent TGV-49
Year: 2025
Type: article
Abstract: Introduction Antimicrobial resistance remains a major global public health challenge that necessitates novel drugs with a low resistance rate. Methods Herein, we evaluate TGV-49, a novel broad-spectrum antimicrobial agent, against multidrug-resistant Gram-negative bacteria, including ESKAPE pathogens ( Acinetobacter baumannii , Pseudomonas aeruginosa , and Klebsiella pneumoniae ) and pathogens from agriculture that infect humans ( Ralstonia solanacearum and Aeromonas hydrophila ). Results TGV-49 was highly effective in overcoming resistance to conventional antibiotics. The experimental evolution of A. baumannii using a morbidostat revealed minimal development of resistance. Conclusion Our findings suggest TGV-49 as a potential alternative for combating MDR infections in clinical and agricultural settings.
Source: Frontiers in Antibiotics
Institution: Sanford Burnham Prebys Medical Discovery Institute
Language: English
Subfield: Molecular Medicine
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,353
Awards: G4606905680, G5144927497
OpenAlex ID: W4415799704