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Copper‐Catalyzed Ring‐Opening Cross‐Coupling of Cyclopropanols with Phosphorothioates

Year: 2025
Type: article
Abstract: A copper-catalyzed ring-opening cross-coupling of cyclopropanols with phosphorothioates has been developed. This method efficiently affords diverse γ-carbonyl thiophosphates in medium to high yields under mild conditions. Herein, further studies demonstrate that these thiophosphates can be transformed into thiacyclobutanes with moderate efficiency. Initial mechanistic investigations suggest that the reaction proceeds via a radical pathway or homoenolate intermediate, rather than a Michael addition mechanism.
Source: ChemSusChem
DOI: 10.1002/cssc.202501862
Institutions: Huaqiao University, Xinyu University, Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry, State Key Laboratory of Organometallic Chemistry, Henan Normal University, Fuzhou University, Nanjing University
Language: English
Field: Chemistry
Open Access status: bronze
Funders: Henan Normal University, National Natural Science Foundation of China, Natural Science Foundation of Fujian Province, Huaqiao University, Nanjing University, State Key Laboratory of Coordination Chemistry
OpenAlex ID: W4415802315
FWCI: 1.192
Cites: 52
Cited by: 4
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