Work

Fused 3D boron heterocycles via EnT catalysis: synthesis, modification and validation as beta-lactamase inhibitors

Year: 2025

Type: article

Abstract: analysis, and co-crystallisation with serine β-lactamase CTX-M-14, revealing enantiospecific binding and a well-defined hydrogen bonding network. These results establish a versatile platform for the synthesis of functionalised boron heterocycles with direct translational potential in medicinal chemistry.

Source: Chemical Science

DOI: 10.1039/d5sc05518k

Authors: Hannah M. Kortman, Hao Fang, Kane A. C. Bastick, Charlotte Völkel, Dominik Oberthür, Peter H. Seeberger, Markus Perbandt, John J. Molloy

Institutions: Max Planck Institute of Colloids and Interfaces, Freie Universität Berlin, Deutsches Elektronen-Synchrotron DESY, Center for Free-Electron Laser Science, Universität Hamburg

Language: English

Topic: Organoboron and organosilicon chemistry

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: Fonds der Chemischen Industrie, University of St Andrews, Daimler und Benz Stiftung, HORIZON EUROPE Framework Programme, Deutsches Elektronen-Synchrotron, H2020 European Research Council

Award: G2822772043

OpenAlex ID: W4415802889

FWCI: 0.876

Cites: 84

Cited by: 3

Related to: