Enhanced expression of CXCL1 in renal cell carcinoma facilitates tumor cell malignancy via PI3K/AKT‑dependent mechanisms
Year: 2025
Type: article
Abstract: T cells and neutrophils, as well as microsatellite instability in RCC. Functional studies were also performed, which demonstrated that both exogenous and overexpression of CXCL1 led to a marked enhancement of the proliferative and migratory capacities of RCC cells, whereas downregulation of CXCL1 exerted a suppressive influence on the malignant behaviors of the tumor cells. In addition, western blot analysis experiments revealed that overexpression of CXCL1 in RCC cells was able to regulate the expression levels of phosphoinositide 3-kinase (PI3K)/AKT pathway-associated proteins, including Bcl-2-associated X protein, B-cell lymphoma-2, PI3K and AKT. Finally, the AKT-specific inhibitor GDC-0068 was shown to reverse the promoting effects of CXCL1 on the malignant behaviors of RCC cells. Taken together, the findings of the present study have shown that CXCL1 exhibits high expression patterns in RCC tissues and may serve diverse functions in facilitating various aspects of RCC advancement.
Source: Oncology Letters
Authors: Shiliang Gui, Hongrui Zhang, Huiting Xiao, Chen Liu, Yuhang Wang, Baotian Wang, Hongbin Qiu
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4415804618