Work

Gene expression of cytokines IL-17 and IL-33 in plasma and nasal lavage fluid of patients with allergic rhinitis and bronchial asthma

Year: 2025

Type: article

Abstract: The research presented in this article determined the systemic (blood plasma) and local (nasal lavage fluid) levels of interleukin-17 (IL-17) and interleukin-33 (IL-33) in healthy volunteers, patients with allergic rhinitis (AR), and patients with both allergic rhinitis and recently diagnosed bronchial asthma (AR+BA). IL-17 and IL-33 levels were consistent between AR and AR+BA patients but diverged when comparing either patient group or the combined group of all patients with healthy volunteers. These results indicate that AR and AR+BA patients represent a homogeneous group and suggest a role for IL-17 and/or IL-33 in the progression of AR to AR+BA. In conclusion, our data show that patients with AR only and those who progress to AR+BA from AR alone have elevated IL-17 levels in both nasal lavage fluid (NLF) and serum. This finding is consistent with recent studies and identifies a novel population of AR+BA patients with elevated IL-17 levels. The possibility of novel IL-33 regulatory mechanisms in these patients warrants further research.

Source: Pharmacia

DOI: 10.3897/pharmacia.72.e165215

Authors: Sjoerd Miedema, Dimitrina Georgieva, Kremena Naydenova, Vasil Dimitrov, Tsvetelina Velikova

Institutions: Sofia University "St. Kliment Ohridski", Medical University of Sofia, Ministry of Interior

Language: English

Topic: IL-33, ST2, and ILC Pathways

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $107