Year: 2025
Type: article
Study design: Case Report
Abstract: Introduction: Cutaneous metastases from renal cell carcinoma (RCC) are an uncommon and poorly understood clinical phenomenon that frequently predicts a poor prognosis. Case Presentation: A 69-year-old male with a history of type 2 diabetes and benign prostatic hyperplasia was diagnosed with stage 4 RCC and various cutaneous lesions. A dermatological checkup during his hospitalization revealed asymptomatic subcutaneous nodules and purpuric areas. Biopsy and immunohistochemistry (IHC) staining confirmed the presence of cutaneous metastatic carcinoma, which is consistent with renal cell origin. The immunohistochemistry profile was positive for pancytokeratin, CD10, and vimentin but negative for PAX8, indicating a distinct appearance in RCC patients. Conclusions: This case emphasizes the necessity of recognizing cutaneous metastases as an uncommon presentation of advanced RCC, as well as PAX8's potential role as a diagnostic marker.
Source: Case Reports in Dermatology
DOI: 10.1159/000548441
Authors: Reem Brashi, Murooj Alotaibi, Rehab Fadag, Ahmed Barrashi, Shaimaa Hamza Banaji, Bashayr Nazer, Magdi Abdulghani, Waseem Alhawsawi
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,030
OpenAlex ID: W4415817744