Work

From tetrazole to isoquinolinone: Structure-based optimization and late-stage diversification of AR-C118925-derived P2Y2 receptor antagonists

Year: 2025

Type: article

Abstract: R antagonists.

Source: European Journal of Medicinal Chemistry

DOI: 10.1016/j.ejmech.2025.118335

Authors: Rayan Aboalgasim Makawi Abdalrahman, Katja Schlegel, Victor Hugo Catricala Fernandes, Adeline Dotz, Giuliano Cesar Clososki, Marcel Bermúdez, Anna Junker

Institutions: University of Tübingen, University of Münster, Universidade de São Paulo

Language: English

Topic: Adenosine and Purinergic Signaling

Subfield: Physiology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,650

Funders: Deutscher Akademischer Austauschdienst, Deutsche Forschungsgemeinschaft, Fundação de Amparo à Pesquisa do Estado de São Paulo

Awards: G2032393610, G3423588917, Exploring the medicinal chemical space of aromatics with highly selective synthetic tools, G8137098153, EXC 2180: Individualisierung von Tumortherapien durch molekulare Bildgebung und funktionelle Identifizierung therapeutischer Zielstrukturen (iFIT)

OpenAlex ID: W4415817940

FWCI: 0.559

Cites: 19

Cited by: 1

Related to: