Paramagnetic Rim Lesions in Pediatric Multiple Sclerosis and Their Association With Brain Tissue Atrophy
Year: 2025
Type: article
Study design: Observational Study
Abstract: BACKGROUND AND OBJECTIVES: Paramagnetic rim lesions (PRLs), visible on susceptibility-based imaging (SbI), reflect chronic active inflammation in multiple sclerosis (MS). In adult-onset MS, PRLs are associated with a more aggressive disease course.The objectives of this study were to assess the prevalence of PRLs in children with MS and to examine how baseline PRL count relates to clinical disability and brain tissue volume loss, both cross-sectionally and over short-term follow-up. METHODS: We retrospectively analyzed pediatric patients from 4 UK tertiary neuroimmunology centers who met the 2017 McDonald diagnostic criteria and had 3D T1-weighted, T2-weighted, fluid-attenuated inversion recovery, and SbI MRI available. PRLs were identified per North American Imaging in MS criteria and anatomically classified. Brain volumes were segmented using Mindglide, with z-scores derived from NIH normative data. Associations between baseline PRL burden, clinical variables, and brain volumes were assessed using univariable and multivariable stepwise regression. Linear mixed-effects models evaluated the predictive value of baseline PRL burden on longitudinal brain volume changes. RESULTS: = 0.036). DISCUSSION: PRLs are common in pediatric MS and are linked to greater lesion burden and gray matter atrophy. These findings suggest that PRLs are promising imaging biomarkers of more severe brain tissue damage although their ability to predict future disability requires confirmation in longer term studies.
Authors: Riccardo Nistri, Ermelinda De Meo, Nee Na Kim, Valeria Pozzilli, Philip Goebl, Mario Sa, Sithara Ramdas, Amitav Parida, Sukhvir Wright, Evangeline Wassmer, Michael Eyre, Ming Lim, Thomas Rossor, Cheryl Hemingway, Asthik Biswas, Sniya Sudhakar, Kshitij Mankad, Arman Eshaghi, Frederik Barkhof, Olga Ciccarelli, Yael Hacohen
Institutions: Great Ormond Street Hospital, National Hospital for Neurology and Neurosurgery, UCL Queen Square Institute of Neurology, University College London, Università Campus Bio-Medico, Campus Bio Medico University Hospital, John Radcliffe Hospital, University of Oxford, Birmingham Children's Hospital, Aston University, National Health Service, King's College London, Guy's and St Thomas' NHS Foundation Trust, Evelina London Children's Healthcare, King's College Hospital, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, National Institute for Health and Care Research, UCL Biomedical Research Centre
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,450
OpenAlex ID: W4415825664