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Dipyridamole Attenuates Experimental Peri-Implantitis By Regulating M1 Macrophage Polarization

Year: 2025
Type: article
Abstract: Aim or purpose To investigate the therapeutic effects of dipyridamole within an experimental rat model of peri-implantitis. Materials and methods The animal experiment was approved by ethics committee. Thirty 6-8-week-old male Sprague-Dawley rats received bilateral maxillary first molar extractions with immediate micro-implant placement. After 6 weeks, they were randomized into control (C), ligature and P.g co-induced peri-implantitis (PI), and PI with dipyridamole treatment (20 mg/kg/d, PI+D) groups (n=10/group). Five rats per group were euthanized at 4 and 8 weeks, respectively. Micro-CT quantified peri-implant bone loss. Hematoxylin-eosin staining evaluated peri-implant tissue destruction. Inflammatory cytokines (IL-1β, IL-6, TNF-α) were assessed via immunohistochemistry. Macrophage infiltration and M1 polarization were analyzed by immunofluorescence. One-way ANOVA with Bonferroni correction was used for statistical analysis. P < 0.05 was considered statistically significant. Results Micro-CT analysis conducted 8-week post-ligation demonstrated significantly greater peri-implant bone loss in the PI group compared with the C group (P < 0.05), whereas dipyridamole intervention in the PI+D group effectively attenuated bone loss (P < 0.05). Histopathological evaluations revealed substantially reduced degradation of both soft and hard tissues. In addition, the expression of pro-inflammatory mediators (IL-1β, IL-6, TNF-α) and M1 macrophage polarization markers were significantly downregulated in the PI+D group compare to the PI group (P < 0.05). Conclusions Dipyridamole alleviated experimental peri-implantitis via suppression of macrophage M1 polarization, emerging as a hopeful pharmacological remedy for peri-implantitis.
Authors: Song Jiaying, Huang Baoxin, Li Xingyi, Li Zhipeng, Chen Danying, Li Jiangbo
Language: English
Subfield: Oral Surgery
Field: Dentistry
Open Access status: gold
Estimated APC paid: $2,550
OpenAlex ID: W4415831447
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