Association study between the neurexin‐1 gene and tardive dyskinesia
Year: 2017
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: Tardive dyskinesia (TD) is a motor side effect that may develop after long-term antipsychotic treatment. Schizophrenia has recently been associated with the Neurexin-1 (NRXN1) gene that codes for a cell adhesion molecule in synaptic communication. METHODS: This study examined five NRXN1 single-nucleotide polymorphisms (SNPs) for possible association with the occurrence and severity of TD in 178 schizophrenia patients of European ancestry. RESULTS: We did not find these SNPs to be significantly associated with TD. CONCLUSIONS: More research is needed with additional SNPs and in bigger samples before we can completely rule out the role of NRXN1 in TD.
DOI: 10.1002/hup.2568
Institutions: Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Charité – Universitätsmedizin Berlin, University of Toronto, University of California, Irvine, University of North Carolina at Chapel Hill, Northwestern University, Chemistry of Life Processes Institute
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2582330345