Work

Chemo‐Divergent Friedel–Crafts Alkylation and Friedel–Crafts Acylation of Arenes with α ‐Diazo Ketones Tuned by Reaction Conditions

Year: 2025

Type: article

Abstract: A chemo‐divergent Friedel–Crafts alkylation and Friedel–Crafts acylation of arenes with α ‐diazo ketones has been developed. In this reaction, Cu(OTf) 2 catalyzed the Friedel–Crafts alkylation via Cu‐carbene intermediate, while hexafluoroisopropanol (HFIP) promoted the Friedel–Crafts acylation via the ketene intermediate. This protocol provides a controllable aromatic C(sp2)H bond functionalization of arenes by tuning the reaction conditions.

Source: Chemistry - Methods

DOI: 10.1002/cmtd.202500108

Authors: Xinrong Zhi, Xinyu Huang, Xin Ji, Lu Liu

Institution: East China Normal University

Language: English

Topic: Cyclopropane Reaction Mechanisms

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $2,750

Funder: National Natural Science Foundation of China