Work

P‐Stereogenic Phosphines via Mn(I)‐Catalyzed Asymmetric Hydrophosphination of Vinyl Sulfones: A Case of Solvent‐Induced Stereoinversion

Year: 2025

Type: article

Abstract: In this work, we report a novel approach for synthesizing P‐chiral phosphines through Mn(I)‐catalyzed enantioselective hydrophosphination of vinyl sulfones. A distinctive feature of this system is its solvent‐dependent stereoinversion, which enables the formation of products with opposite configurations using the same catalyst enantiomer. This phenomenon has been demonstrated across a range of vinyl sulfones and diarylphosphines, providing access to both configurations of P‐stereogenic phosphines with a single catalytic system.

Source: Advanced Synthesis & Catalysis

DOI: 10.1002/adsc.70198

Authors: Bin Wan, Syuzanna R. Harutyunyan

Institution: University of Groningen

Language: English

Topic: Organophosphorus compounds synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,650

Funders: China Scholarship Council, European Research Council