Emerging roles of long non-coding RNAs in osteoarthritis: from molecular mechanisms to therapeutic opportunities
Year: 2025
Type: article
Abstract: Long non-coding RNAs (lncRNAs) exert a significant influence on the occurrence and progression of osteoarthritis (OA). LncRNAs are characterized by their multifunctional nature, capable of regulating the expression, transcription, translation, and structural function of target genes through various mechanisms, spanning epigenetic, transcriptional, post-transcriptional, and post-translational levels. This review examines the mechanisms and functions of lncRNAs in cell proliferation, differentiation, apoptosis, extracellular matrix (ECM) degradation, and inflammatory responses in chondrocytes, synovial cells, and mesenchymal stem cells (MSCs) from mice and humans associated with OA. We emphasize the integral role of lncRNAs in the OA disease process. Conclusively, we present insights into OA treatment from the perspective of targeting lncRNAs, addressing future development prospects and potential clinical applications.
Source: RNA Biology
Authors: Yiming Zhao, Yanyan Zhang, Yuan Peng, Zheng Zheng, Qijing Li, Jiefei Shen, Hang Wang, Fei Liu
Institutions: Sichuan University, State Key Laboratory of Oral Diseases
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,175
Awards: G3241995084, G3590280445, G7513332504
OpenAlex ID: W4415850954