Work

spook haploinsufficiency exacerbates aging-related motor impairments

Year: 2025

Type: article

Abstract: heterozygous flies with reduced brain ecdysone exhibit accelerated, aging-related declines in climbing performance in a stimulus-induced negative geotaxis assay, without affecting basal activity. These findings implicate ecdysone signaling as a critical regulator of aging-sensitive motor function and suggest a conserved steroid pathway contributing to AMI across species.

Source: PubMed

DOI: 10.17912/micropub.biology.001871

Authors: Veronica C. Ciliberto, Maya Solis, Carolyne Chepkosgei, Paul Rafael Sabandal, Kyung-An Han

Institution: The University of Texas at El Paso

Language: English

Topic: Genetics, Aging, and Longevity in Model Organisms

Subfield: Aging

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4415854849