Work

Expansion strategies for Vδ2 γδT cells in cancer immunotherapy: Activation, cytokines, and culture conditions

Year: 2025

Type: article

Abstract: The γδT cells are an emerging class of immune effectors with potent antitumor activity, bridging innate and adaptive immunity. Their unique ability to recognise stress-induced ligands independently of major histocompatibility complex restriction makes them attractive candidates for cancer immunotherapy. However, the clinical application of γδT cells requires efficient in vitro expansion strategies to generate large numbers of functional cells. This mini-review explores the latest advancements in γδT cell expansion protocols, focusing on key activation stimuli, cytokine support, and culture conditions that optimise proliferation and cytotoxicity.

Source: World Journal of Clinical Oncology

DOI: 10.5306/wjco.v16.i10.110466

Authors: Natalia Lehman, Michal Zarobkiewicz

Institution: Medical University of Lublin

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Uniwersytet Medyczny w Lublinie