Emergence of co-resistance to imipenem/relebactam and ceftazidime/avibactam in clinical Klebsiella pneumoniae ST11 clone due to KPC-2 N132S and CTX-M-65 S130G/P167S substitutions
Year: 2025
Type: article
Abstract: ABSTRACT Two episodes of imipenem/relebactam and ceftazidime/avibactam co-resistant Klebsiella pneumoniae infections were identified in a Chinese hospital with an 8-month interval. All strains belonged to the ST11-KL64 clone, with pairwise SNP distances ranging from 1 to 9, indicating clonal spread. Plasmid-borne bla KPC-157 (KPC-2 N132S substitution) and bla CTX-M-249 (CTX-M-65 S130G/P167S substitutions) conferred resistance to imipenem/relebactam and ceftazidime/avibactam, respectively. The emergence of these novel resistance determinants in the high-risk clone underscores the need for enhanced surveillance.
DOI: 10.1128/aac.00891-25
Authors: Yiqi Fu, Yuchao Zhang, Jun Zhao, Jiahong Xie, Haishen Kong, Tingting Yang, Wei Chen, Min Xu
Language: English
Subfield: Molecular Medicine
Domain: Life Sciences
Open Access status: diamond
Awards: G5050809530, G7661161445
OpenAlex ID: W4415859305