Safety and efficacy of radiofrequency rhizotomy for trigeminal neuralgia in low resource neurosurgical centers
Year: 2025
Type: article
Study design: Observational Study
Abstract: Radiofrequency rhizotomy (RFR) has shown effectiveness for medically refractory trigeminal neuralgia patients; however, implementing RFR in low-resource settings could serve as a viable treatment option. To evaluate the safety and efficacy of RFR as a trigeminal neuralgia (TN) treatment in low-resource centers and identify treatment outcome predictors. A retrospective study was performed for 53 medically refractory TN patients who underwent RFR. Demographics, pain scores, complications, and outcomes were extracted and analyzed. Over 93% of patients significantly reduced visual analog pain scores (VAS) post-intervention (t = 34.64, df = 52, p < 0.001) with a mean difference of 6.66 (95% CI 6.27–7.05) and a Cohen’s d value of 5.54 (95% CI 4.26–6.83), emphasizing clinically meaningful pain reduction with 2.8% recurrence at 12-month follow-up, and higher pretreatment pain scores were linked with recurrence risk (OR = 3.3, 95% CI 1.08–14.88, p = 0.067). Age, gender, and TN distribution are recurrence risk-independent. Similarly, multiple linear regression showed no relationship for the post-procedural pain predictors, such as age (β = − 0.01453, p = 0.5019) and voltage (β = 0.01197, p = 0.7547); however, baseline pain score was positively associated with post-procedural pain score (β = 0.526, p = 0.0168), showing it as a key determinant. Kaplan-Meier described the insignificant recurrence-free survival difference ( p = 1), suggesting successful outcomes over follow-up, while complications were 39.6% of patients with predominant temporary jaw weakness. Radiofrequency rhizotomy is a safe, effective TN management procedure in low-resource settings, highlighting the potential need for functional neurosurgery in developing healthcare systems.
Source: Discover Medicine
Authors: Muhammad Irfan, Iqbal Ahmad, Liaqat Ali Jalal
Institution: Nishtar Medical College and Hospital
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,290
OpenAlex ID: W4415878495