Work

Imaging manifestations of brain metastases in ultra-long delay-enhanced MRI > 60 min

Year: 2025

Type: article

Abstract: Purpose To compare the imaging manifestations of BM at 3-min and >60-min delayed-enhanced MRI and explore their imaging characteristics and changing patterns in ultra-long delayed-enhanced MRI >60 min. Twenty-six participants with BM were prospectively enrolled from May to October 2019. Contrast-enhanced (CE) T1-weighted imaging (T1WI) was performed for 3 min and >60 min after contrast injection. BM were defined as regions of interest (ROI -3min and ROI -60min ). The two ROIs were fused (ROI -total ); the additional display area of the lesion at 3-min (ROI -A ) and >60-min (ROI -B ) was determined. Signal intensity (SI), volume, and shape differences between ROIs and brain white matter were compared; the imaging characteristics of BM on ultra-long delayed-enhanced MRI were analyzed. Twelve males (age: 37–72 [median: 62] years) and 14 females (age: 41–79 [median: 61] years) were included. BM were divided into disappeared (n = 79, 38.0%) and non-disappeared (n = 129, 62.0%) groups. The average volume of the two groups at 3-min was 0.18 ± 0.25 and 3.53 ± 10.47 cm 3 ( p <.05). At >60-min, BM in the non-disappeared group had four imaging manifestations: adduction (95.3%), abduction (72.7%), signal reversal (10.1%), and filling (38%) effects. In the non-disappeared group, ROI -3min , ROI -60min , ROI -total , ROI -A , and ROI -B volumes averaged 3.53 ± 10.47, 3.72 ± 11.51, 4.06 ± 11.76, 0.36 ± 0.54, and 0.54 ± 1.48 cm 3 ( p <.05). The DSC obtained from ROI -3min compared to ROI -60min was largest in the >5 cm 3 group. BM changed significantly in >60-min delayed CE T1WI; no consistent regularity was observed. • The imaging manifestations of ultra-long delay-enhanced MRI were quantified • The imaging characteristics and changing patterns of BM in ultra-long delayed-enhanced MRI >60 min were explored • Four imaging manifestations were observed, namely adduction, abduction, signal reversal, and filling • Volume was the key factor affecting the imaging of BM in ultra-long delayed-enhanced MRI >60 min

Source: Brain Research Bulletin

DOI: 10.1016/j.brainresbull.2025.111622