Work

Exploring the formation of medium-sized cyclic amines within self-assembled yoctoliter inner-spaces

Year: 2025

Type: article

Abstract: S N 2 cyclizations in yoctoliter capsules are in competition with guest hydrolysis by adventitious water. Nevertheless, the synthesis of medium size rings can be carried out in the inner-space, and performed catalytically in the formation of azepane.

Source: Chemical Science

DOI: 10.1039/d5sc07390a

Authors: Yahya A. Ismaiel, Douglas Rogers, Bruce C. Gibb

Institution: Tulane University

Language: English

Topic: Supramolecular Chemistry and Complexes

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: National Science Foundation, Division of Chemistry

Awards: G2145627834, MRI: Acquisition of a 600 MHz NMR Spectrometer, G3875468104, Supramolecular Design of Novel Reagents and Organo-Catalysts for Aqueous Solution