Work

Modeling the effect of glucagon on endogenous glucose production in healthy individuals under meal-like conditions

Year: 2025

Type: article

Abstract: The model can be used to quantify hepatic glucagon and insulin sensitivity, accounting also for glucagon evanescence over time. The ability to quantify glucagon effects on postprandial glucose metabolism will further our understanding of its role in the onset and progression of type 2 diabetes. These findings can also be used in the design of novel glucagon-based therapies where accurate modeling of glucagon action is required to meet efficacy and safety standards.

Source: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

DOI: 10.1152/ajpregu.00172.2025

Authors: Edoardo Faggionato, Alessio Tonello, Marcello C. Laurenti, Adrian Vella, Chiara Dalla Man

Institutions: University of Padua, Mayo Clinic

Language: English

Topic: Pancreatic function and diabetes

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: National Institute of Diabetes and Digestive and Kidney Diseases