Work

Cuproptosis-related gene TMPO affects the healing of diabetic foot ulcers through TGF-β/Smad signaling pathway

Year: 2025

Type: article

Abstract: animal experiments revealed that TMPO knockdown reduced inflammation, improved tissue regeneration, enhanced microvascular and collagen formation, and facilitated wound healing. Our study established a connection between DFU and cuproptosis, identifying that TMPO regulates diabetic wound healing through the TGF-β/Smad signaling pathway. These findings provide new insights and potential strategies for DFU treatment.

Source: iScience

DOI: 10.1016/j.isci.2025.113932

Authors: Xiaoxiang Wang, Wentao Chen, Wenlian Zheng, Fujun Wang, Lusheng Xu, Sitong Zhou, Ronghua Yang

Institutions: The First Affiliated Hospital, Sun Yat-sen University, Foshan Second People's Hospital, Qiqihar Medical University, Heyou Hospital, First People's Hospital of Foshan, Guangzhou First People's Hospital, Guangzhou Medical University

Language: English

Topic: Wound Healing and Treatments

Subfield: Rehabilitation

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240

Funders: National Natural Science Foundation of China, Basic and Applied Basic Research Foundation of Guangdong Province

Awards: G7032503342, G7449771104, G8046813125

OpenAlex ID: W4415901284

FWCI: 0.627

Cites:

Cited by: 2

Related to: