Work

Targeted literature review and assessment of evidence in microvillus inclusion disease (MVID)

Year: 2025

Type: article

Abstract: Background & Aims Microvillous inclusion disease (MVID) is a rare, severe congenital disorder characterized by intractable diarrhea and life-threatening complications, including dehydration, malnutrition, intestinal failure, and eventually death. This review aims to synthesize reported evidence on MVID's clinical manifestations, treatment, and outcomes, highlighting the disease burden and identifying key gaps in current knowledge. Methods A literature review was conducted on 83 publications, including case reports and cohort studies. Studies were selected based on clinical or epidemiological data on MVID, focusing on diagnostics, treatment, and patient outcomes. Results MVID typically presents in neonates with severe diarrhea that rapidly leads to dehydration and 523 malnutrition. MVID is associated with frequent complications and high mortality (30%) reflecting the disease's severity and limitations of current treatments. Most patients remain lifelong dependent on total parenteral nutrition (TPN), increasing risks and burden. The review also revealed a lack of consistent epidemiological data and variability in clinical management. Discussion Findings underscore the need for standardized diagnostic protocols and treatment strategies. Scarcity of evidence and heterogeneity in management highlight the necessity of more comprehensive studies to improve patient outcomes. Conclusion Addressing these gaps could optimize care and reduce MVID-associated complications. Future research should focus on robust clinical guidelines and long-term data collection to improve treatment outcomes and survival rates.

Source: Clinical Nutrition Open Science

DOI: 10.1016/j.nutos.2025.10.007