Work

Hepatitis-associated Vs Idiopathic Paediatric Aplastic Anaemia: Clonal Architecture and Disease Trajectory

Year: 2025

Type: article

Abstract: Background and Aims: Between 2004 and 2025, 72 paediatric patients were treated for aplastic anaemia (AA) in the Czech Republic, comprising 43 idiopathic and 29 hepatitis-associated (HA-AA). Among HA-AA patients, 21 were classified as AA, and 8 as refractory cytopenia of childhood (RCC). 20 of 29 HA-AA patients were male. Of 43 idiopathic AA patients, 12 received upfront HSCT and 31 IST (13 later transplanted); in HA-AA, 7 received upfront HSCT and 22 IST (9 later transplanted). Two patients required liver transplantation.

Source: EJC Paediatric Oncology

DOI: 10.1016/j.ejcped.2025.100362