Work

In-vivo Mouse Model of Acute Myeloid Leukemia Development in Congenital Neutropenia

Year: 2025

Type: article

Abstract: Background and Aims: Progression to acute myeloid leukemia (AML) is detected in approximately 20% of patients with congenital neutropenia (CN) after 20 years and is frequently associated with co-occurring mutations in RUNX1 and CSF3R. The hypothesis sets CN as a pre-leukemic condition, in which the acquisition of somatic mutations in RUNX1 and CSF3R drives leukemia progression. Here, we aim to establish an in vivo model of CN-neoplasms to investigate the clonal architecture induced by the accumulation of cooperative somatic mutations and their leukemogenic potential.

Source: EJC Paediatric Oncology

DOI: 10.1016/j.ejcped.2025.100333

Authors: Jérémy Haaf, Malte Ritter, Patricia Arreba-Tutusaus, Siarhei Kandabarau, Maksim Klimiankou, Julia Skokowa

Institutions: Universitätsklinikum Tübingen, University of Tübingen

Language: English

Topic: Blood disorders and treatments

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,340