Work

Recommendations for management of pregnancy complicated by Caroli disease: A case report and literature review

Year: 2025

Type: article

Abstract: We investigated the clinical and genetic characteristics of a 28-year-old pregnant Chinese woman with Caroli disease (CD) and systematically reviewed the published literature on pregnancy complicated by CD. We reviewed our case and 8 patients with 9 pregnancies included in 6 reports. The main clinical characteristics of pregnancy complicated by CD are cholestasis, liver and renal insufficiency, portal hypertension, and cirrhosis. In severe cases, there may be an increased risk of disease progression during pregnancy. Management of pregnancy complicated by CD is primarily supportive. Antimicrobial therapy and prevention of cholestasis and portal hypertension are recommended. Patients may benefit from multidisciplinary care.

Source: iLiver

DOI: 10.1016/j.iliver.2025.100199

Authors: Chen Liang, Li Bai, Wei Hou, Wen-Yan Song, Yun-Xia Zhu, Su-Jun Zheng

Institutions: Capital Medical University, Beijing Jishuitan Hospital, Beijing YouAn Hospital

Language: English

Topic: Pediatric Hepatobiliary Diseases and Treatments

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,600