Work

Plasma interferon predicts pulmonary hypertension severity and outcome

Year: 2025

Type: article

Abstract: Background: Pulmonary hypertension (PH) is a complex and progressive disease characterized by elevated pulmonary vascular resistance. Inflammation plays an important role in the pathogenesis of PH. Interferons (IFNs) are key immune cytokines that regulate cellular responses to various stimuli. This study aimed to investigate the association between IFN levels and the risk and prognosis of PH. Methods: A cohort of 875 PH patients and 182 matched controls were included in this study. Logistic regression models and receiver operating characteristic (ROC) curves were applied to evaluate the association between IFN levels and PH risk. Correlations between variables were assessed using Spearman's rank correlation coefficient (r ). Cox proportional hazards regression and Kaplan-Meier survival curves were used to assess the prognostic value of IFNs levels. The predictive performance of prognostic models was assessed using ROC analysis and decision curve analysis and a nomogram was constructed to estimate individual overall survival probabilities. Results: < 0.001). A prognostic model combining IFN-α with traditional clinical markers, such as WHO-FC, 6-MWD, and NT-proBNP, improved predictive accuracy, with IFN-α contributing additional clinical net benefit in risk stratification. Conclusions: These findings suggest that plasma IFN-α may serve as a valuable biomarker for both predicting PH risk and assessing prognosis.

Source: Frontiers in Cardiovascular Medicine

DOI: 10.3389/fcvm.2025.1634764