Work

CD81 inhibits the proliferation of acute megakaryoblastic leukemia cells

Year: 2025

Type: article

Abstract: CD81 is a cell surface protein that plays an important part in tumor development. Several studies have shown that CD81 plays a role in cancer cell proliferation, invasion, and metastasis, particularly in leukemia. It has been reported that CD81 is overexpressed in non-Down syndrome acute megakaryoblastic leukemia (non-DS AMKL). In this article, we hypothesize that CD81 may play a vital role in acute megakaryoblastic leukemia (AMKL). We constructed the CD81 knockdown cell line using shRNA and found that CD81 knockout can inhibit the proliferation of AMKL and increase the apoptosis of AMKL in vitro . Therefore, CD81 may be a target of AMKL.

Source: PeerJ

DOI: 10.7717/peerj.20286

Authors: Narun Su, Xiaohao Hu

Institutions: Fujian Medical University, Second Affiliated Hospital of Fujian Medical University

Language: English

Topic: Acute Myeloid Leukemia Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,395