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Spindle Cell Carcinoma: A Rare and Aggressive Variant of Squamous Cell Carcinoma of the Upper Lip

Year: 2025

Type: article

Abstract: ABSTRACT: Spindle cell carcinoma (SpCC), also known as sarcomatoid carcinoma, is a rare biphasic malignant neoplasm ranging variably from reactive to malignant making it critical and relatively challenging where tumors have areas of squamous cell carcinoma (SCC) admixed with areas of pleomorphic tumor. It is a rare variant of SCC characterized by malignant spindle-shaped cells resembling sarcomas. Spindle cell lesions of the head and neck are diverse with great clinical and biological variety. They tend to show rapid progression with a high recurrence rate and the ability to metastasize, all of which contribute to their poor prognosis.

Source: Annals of African Medicine

DOI: 10.4103/aam.aam_201_25

Authors: Prabhat Bhaskarrao Nichkaode, Rishika Mishra

Institutions: Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D.Y. Patil Vidyapeeth, Pune

Language: English

Topic: Head and Neck Cancer Studies

Subfield: Otorhinolaryngology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4415914727

FWCI:

Cites: 5

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