Work

Dual-functional nitrogen-doped carbon dot/copper oxide nanocomposites for electrochemical sensing of ascorbic acid and antimicrobial applications

Year: 2025

Type: article

Abstract: BACKGROUND: Antimicrobial resistance poses a growing threat to effective infection treatment, while imbalances in ascorbic acid (AA) levels are linked to various health issues. Nanotechnology offers innovative solutions, with carbon dot-based nanocomposites emerging as promising materials for both antimicrobial applications and sensitive detection of biomolecules. This study aimed to synthesize nitrogen-doped carbon dots (NCDs), copper oxide nanoparticles (CuO NPs), and their nanocomposites (CuO-NCDs), and to evaluate their electrochemical sensing of AA and antimicrobial activity. METHODS: NCDs were prepared via a hydrothermal treatment of citric acid and urea, and CuO NPs by precipitation of copper nitrate. Characterization by Ultraviolet-Visible (UV-Vis) spectroscopy, Fourier Transform Infrared (FT-IR) spectroscopy, X-ray Diffraction (XRD), and Scanning Electron Microscopy (SEM) confirmed their optical properties, functional groups, crystallinity, and morphology. RESULTS: The CuO-NCD nanocomposite exhibited enhanced optical absorption with a reduced energy band gap (2.6 eV) compared to individual components. Electrochemical tests revealed a detection limit of 2.56 µM for AA and increased electrode surface area, indicating improved sensitivity and selectivity. Antimicrobial assays showed significant activity against Staphylococcus aureus, with a 24 mm inhibition zone at 200 mg/mL after 24 h. CONCLUSIONS: These results demonstrate that CuO-NCD nanocomposites hold potential as dual-function materials for effective AA detection and combating microbial infections.

Source: BMC Chemistry

DOI: 10.1186/s13065-025-01639-3

Authors: Zerfu Haile Robi, Dugasa Jabesa Nemera, Tekileab Engida Gebremichael, Guta Gonfa Muleta

Institutions: Oda Bultum University, Jimma University, Gambella University

Language: English

Topic: Carbon and Quantum Dots Applications

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,990