Work

Reducing astigmatism following accelerated transepithelial corneal collagen cross-linking for keratoconus: A prospective study

Year: 2025

Type: article

Abstract: The purpose of this study was to evaluate the functional and corneal structural outcomes in the young population of keratoconus before and after accelerated transepithelial corneal collagen cross-linking (ATE-CXL) at 9 mW/cm2 for 10 minutes. In this prospective cohort study, ATE-CXL was performed on 36 eyes. The best-corrected visual acuity, spheris, astigmatism, K1, K2, Kmean, central corneal thickness, and intraocular pressure (IOP) were all evaluated. The follow-up time ranged from 2 weeks to 6 months after the procedure. The best-corrected visual acuity results improved significantly from 2 weeks (P <.001), 1.5 months (P <.001), and at 6 months postoperation (P <.001). ATE-CXL significantly reduced the patients' astigmatism after 6 months (P = .03). Following the procedure, there was a modest reduction in the K1, K2, and Kmean in the keratoconus patients. The intraocular pressure and central corneal thickness did not differ significantly at different time points. No postoperative complications were discovered following the procedure. ATE CXL demonstrated an early improvement in the patients' visual acuity and astigmatism in the Indonesian young population, and it was regarded as a safe and efficient keratoconus treatment. Further research with larger sample sizes and longer follow-up periods are required to confirm these findings.

Source: Medicine

DOI: 10.1097/md.0000000000045003

Authors: Reny Setyowati, Rifa Widyaningrum, Supanji Supanji, Khadijah Zai, Agus Supartoto

Institutions: Universitas Gadjah Mada, Rumah Sakit Umum Pusat Dr. Sardjito

Language: English

Topic: Corneal surgery and disorders

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,950