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BisBINOL-Based Fluorescent Probes: Effect of Alkane Linkers and Chemo- and Enantioselective Recognition of Arginine

Year: 2025

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide A series of bisBINOL-based fluorescent probes, which contain two BINOL units linked by an alkane chain of varying length, were synthesized and characterized. It was found that the chain length of the alkane linker has strong effect on the fluorescence response of these compounds toward amino acids. Among them, compound ( S, S )- 6 that contains a six-carbon alkyl chain linker exhibits highly chemoselective and enantioselective fluorescence enhancement with arginine in the presence of Zn 2+, but other compounds show much less selective fluorescence response. Spectroscopic studies have been conducted to investigate the mechanism of this process.

Source: The Journal of Organic Chemistry

DOI: 10.1021/acs.joc.5c01699

Authors: Yichen Li, Carson Patrick, Franklin He, Sydney Rohrbach, Yifan Mao, Lin Pu

Institution: University of Virginia

Language: English

Topic: Molecular Sensors and Ion Detection

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: National Science Foundation, Division of Chemistry