Work

Mechanistic target of rapamycin complex-2 mediates the effect of overnight high K + on Kir4.1/Kir5.1 in the DCT and ENaC/ROMK in ASDN

Year: 2025

Type: article

Abstract: Our study has two novel findings. First, we demonstrate that mTORc2 plays a key role in mediating high-K + -intake-induced stimulation of ENaC/ROMK activity in late DCT. Second, we demonstrate that overnight-HK-induced stimulation of kidney K + excretion is achieved by simultaneously stimulating ENaC and ROMK in the late DCT, CNT, and CCD, and inhibiting Kir4.1/Kir5.1 in the DCT. Thus, we have illustrated an integrated mechanism by which mTORc2 regulates kidney K + excretion.

Source: American Journal of Physiology-Renal Physiology

DOI: 10.1152/ajprenal.00291.2025

Authors: Xin-Peng Duan, Jun-Ya Zheng, Cheng-Biao Zhang, Shafig Alam, Wen-Hui Wang, Dao-Hong Lin

Institutions: Xuzhou Medical College, New York Medical College

Language: English

Topic: Ion Transport and Channel Regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases