Work

Rewriting the radiation playbook: NSABP B-51 and the rise of pathologic precision

Year: 2025

Type: article

Abstract: The NSABP B-51/RTOG 1304 trial represents a paradigm shift in breast cancer management, showing that patients achieving nodal clearance after neoadjuvant chemotherapy derive no added benefit from regional nodal irradiation. These results challenge long-standing practice, promotes de-escalation, and raise biologically significant questions, particularly regarding immunologic mechanisms and clinical subgroup variations.

Source: npj Breast Cancer

DOI: 10.1038/s41523-025-00819-7

Authors: Mehran Habibi, Bruce G. Haffty, Silvia C. Formenti

Institutions: Baptist Hospital of Miami, Florida International University, Rutgers Cancer Institute, Weill Cornell Medicine

Language: English

Topic: Breast Cancer Treatment Studies

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,790