Work

Valence State and Oxygen Vacancy Engineering via Vanadium Doping in NiFe-LDHs for Highly Sensitive Non-enzymatic Glucose Detection

Year: 2025

Type: article

Abstract: The growing global burden of diabetes necessitates the development of highly sensitive, stable, and cost-effective glucose-sensing technologies. Non-enzymatic electrochemical glucose sensors (NEGS) based on layered double hydroxides (LDHs) provide a durable and tunable alternative to enzyme-based sensors. Herein, we report a vanadium-doped nickel–iron LDH (NiFe₁₋ₓVₓ-LDH) system, hydrothermally grown on nickel foam, for enhanced glucose detection. Structural and spectroscopic analyses confirm that optimal vanadium incorporation (x = 0.4) modulates the lattice structure and defect chemistry, forming hierarchical nanoflower-like architectures with enhanced electroac ve surface area. These features facilitate enhanced Ni²⁺/Ni³⁺ and V⁴⁺/V⁵⁺ redox transi ons, improving charge transport and glucose oxidation kinetics. The optimized NiFe₀.₆V₀.₄-LDH electrode exhibits a high sensi vity of 1.891 mA mM⁻¹ cm⁻², a low detec on limit of 2.228 μM, and excellent stability. This work highlights the synergistic role of valence-state engineering and defect modulation in designing advanced NEGS platforms, offering promising potential for future electrochemical sensing applications.

Source: Journal of Electrochemical Science and Technology

DOI: 10.33961/jecst.2025.00906